Following the Nobel Prize awarded in 1998 for the discovery and function of Nitric Oxide (which up until then had been regarded as a noxious gas) an enormous amount of research has been undertaken to better understand the functions of this neurotransmitter in various physiological conditions as well as acute and chronic pathological conditions such as pain, Parkinson’s disease, Alzheimer’s disease, traumatic brain injury, stroke, inflammatory disease etc. Apart from Nitric Oxide, two other gaseous neurotransmitters, Hydrogen Sulfide and Carbon Monoxide, have become the focus of biologists and chemists alike to explore the significance of these neurotransmitters in inflammation and gastric mucosal protection.
- Biology: Discovery and function of gaseous neurotransmitters and mediators, including hydrogen sulfide and carbon monoxide
- Pharmacology: Pain, inflammation, immunology, CNS, TBI
- Structure: X-Ray structures on ligand bound enzymes
- Chemistry: Donors and inhibitors - therapeutic implications
- Clinical applications